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Etizolam is an effective anti-anxiety which is similar to benzodiazepine class of medicines.

It is use for management of anxiety and short-term treatment in insomnia that is sleeplessness. Its specially good at relieving anxiety. Etizolam can make you feel relaxed and calm. It is marketed for medicinal use as a sedative-hypnotic drug with muscle-relaxing, anti-anxiety properties and insomnia-reducing. It is a thienodiazepine available in a number of countries.

Etizolam is similar chemically to benzodiazepines such as diazepam it also has comparable central nervous system depressant effects. It has anxiety-reducing, anticonvulsant, sedating and muscle-relaxing effects like valium and other benzodiazepines. It is effective then this medicines.

It differs from BDZs in having a benzene ring replaced with thiophene ring. It is agonist at GABA-A receptors and possesses amnesic, anxiolytic, hypnotic, anticonvulsant, sedative and skeletal muscle relaxant properties.

Etizolam was initially introduced in 1983 in Japan as treatment for neurological conditions such as anxiety and sleep disorders. It is marketed in many countries like Italy, Japan and India.

In rat study the amounts of etizolam excreted was 70% in feces was 30%in urine, while the values in a mouse study were 60% in feces and 40% in urine.The average elimination half-life of etizolam following a one oral dose of 0.5mg is 3 to 4 hours but may be increased up to 17 hours depending on the rate of metabolism. The main metabolite α-hydroxyetizolam displays a longer elimination half-life of 8.2 hours.

Anxiety
This medicine is used as a treatment for and manage anxiety conditions characterized by agitation, hyperactivity, panic, sweating of palms, etc. under normal circumstances.

Insomnia
This medicine is utilized for short-term management of insomnia characterized by an inability to sleep in addition to associated symptoms like fatigue, irritation and memory loss.

Major and minor side effects for Etizolam

  • Drowsiness
  • Muscle weakness
  • Sleepiness
  • Headache
  • Vertigo
  • Confusion
  • Slurred speech
  • Uncontrolled shaking of arms or legs
  • Change in libido
  • Visual disturbances
  • Urinary retention/incontinence
  • Stomach discomfort and pain
  • Memory problems
  • Excessive salivation

Frequently asked question

Begin the process of action
The result of this medicine can be observed within 30-60 minutes of oral administration.

Duration of effect
The
 effect of this medicine is relentless for an average duration of 6-8 hours which could extend further in case of a long and uninterrupted sleep after consumption.

Careful with alcohol?
Avoid the uptake of alcohol while taking this medicine. Never perform physical activities requiring mental alertness after taking this medicineContact your doctor and look for advice if negative effects are experienced.

Could it be habit forming?
This medicine possesses a moderate habit-forming potential.

Usage in pregnancy?
Using of this medicine in women who are pregnant is not recommended. Your physician will prescribe a safer alternative after assessing the condition.

Usage while breast-feeding?
Using of this medicine in breastfeeding women would not be recommended. Your doctor will prescribe a safer alternative after assessing the condition.

  1. Myasthenia gravisThis medicine would not be recommended for usage in case you have a neuromuscular condition in which the muscles tire rapidly, causing severe weakness along with other complications.
  2. Narrow angle glaucomaThis medicine is certainly not recommended in order to use if you suffer from narrow angle glaucoma.
  3. PorphyriaThis medicine is certainly not recommended for use if you have this rare disease of the blood.
  4. AllergyThis medicine is certainly not recommended for use in case you have a known history of allergy to Etizolam or any other ingredients present along with it.

Warnings for special people

Pregnancy

Use of the medicine in women who are pregnant is not recommended. Your doctor will prescribe a safer alternative after assessing the condition.

Breast-feeding

Use of the medicine in breastfeeding women is not recommended. Your health care provider will prescribe a safer alternative after assessing the condition.

General warnings

Thoughts of suicide and behaviour

Use of this medicine may cause thoughts of suicide and inclinations and thus it should be given with extreme caution in patients having mental problems like depression, chronic psychoses,phobias etc.

Impairment of liver/kidney function

This medicine really should be utilized with caution if you have an impairment of normal liver or kidney function. Appropriate dose adjustments and monitoring of liver/kidney function during treatment are highly recommended.

Alcohol/drug addiction

This medicine should be used with extreme caution in patients with a history of alcohol or recreational drug abuse. The risk of severe adverse effects is significantly high in such cases.

Drowsiness and confusion

Use of this medicine may cause drowsiness, confusion, impairment of thoughts and perception etc. It is advised to refrain from activities that require a high level of mental alertness after taking this medicine.

Fall in blood pressure

Use of this medicine in high doses can cause a fall in blood pressure leading to headaches, fainting etc. It should be used with caution in patients having a higher/lower blood pressure than normal.

Use in the elderly

This medicine should be used with caution in the elderly and bedridden patients as the risk of adverse effects are higher than normal patients.

Personality disorder

This medicine should be used with caution in patients having personality disorders or Organic brain syndrome.

Withdrawal symptoms

The use of this medicine should not be stopped abruptly as you are likely to experience symptoms like convulsions, behavioural disorder, tremor, and anxiety. A gradual reduction in the dose quantity is advised.

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